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Comparison of Fractional Anisotropy Variances in the Trigeminal Nerve at Root Entry and Cisternal Segment Zones in Patients with and without Clinical Features of Trigeminal Neuralgia: A Cross-sectional Study |
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Athotata Sai Preethi, Vadana Balamurali Krishna, Velicheti Sandeep, Hanumanthu Manasa Mayukha, Marineni Anveeksha, Kondraguntata Chandrasekhar 1. Postgraduate, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. 2. Professor, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. 3. Professor, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. 4. Postgraduate, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. 5. Postgraduate, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. 6. Professor and Head, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Vijayawada, Andhra Pradesh, India. |
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Correspondence Address : Dr. Vadana Balamurali Krishna, Professor, Department of Radiology, Dr. Pinnamaneni SIMS and RF, Gannavaram-521101, Vijayawada, Andhra Pradesh, India. E-mail: vadana.muralikrishna@gmail.com |
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| ABSTRACT |  | ||||||
: Introduction: Although vessel impingement on nerves can be detected using High-resolution steady-state free precession sequences, such as Fast Imaging Employing Steady-state Acquisition (FIESTA), it remains uncertain whether the compression is a physiological variation or a pathological cause of symptoms. A non invasive tool is required to confirm the aetiology, as Microvascular Decompression (MVD) can significantly improve prognosis. Diffusion Tensor Imaging (DTI) is commonly utilised to identify white matter tracts in the brain through tractography, providing valuable insights into neural integrity and potential compression. Aim: To compare the Fractional Anisotropy (FA) value at root entry and cisternal segment zones in patients with and without clinical features of Trigeminal Neuralgia (TN). Materials and Methods: A cross-sectional study was conducted in the Radiology Department, Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Vijayawada, Andhra Pradesh, India, from January 2024 to May 2024. The study included a total of 60 patients, divided into symptomatic (TN) and asymptomatic groups based on clinical diagnostic criteria. FA values were measured bilaterally in the trigeminal nerve zones, including the root entry and cisternal segments. Statistical analysis was used to compare FA values between the symptomatic and asymptomatic groups. Data was analysed using Statistical Package for the Social Sciences (SPSS) software version 21.0. Results: Sixty patients (25 females, 35 males) with a mean±Standard Deviation (SD) age of 41±14 years participated in the present study. Among them, 47 were asymptomatic and 13 presented with symptoms. The FA values at the Root Entry Zone (REZ) (combined right and left-side) were 0.243, and at the cisternal segment (combined right and left-side) were 0.242 in symptomatic patients, compared to FA values of 0.403 at the REZ (combined right and left-side) and 0.414 at the cisternal segment (combined right and left-side) in asymptomatic patients, with a statistically significant difference (p-value=0.001). Conclusion: The present study highlights the potential of FA values derived from DTI metrics to improve diagnostic precision for identifying pathological vascular compression in patients with TN. | |||||||
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| Keywords : Diagnostic precision, Diffusion tensor imaging, Fractional anisotropy, Neurovascular compression, Trigeminal neuralgia | |||||||
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DOI and Others :
DOI: 10.7860/IJARS/2025/73807.3036
Date of Submission: Jun 27, 2024 Date of Peer Review: Sep 09, 2024 Date of Acceptance: Nov 05, 2024 Date of Publishing: Jan 01, 2025 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was Ethics Committee Approval obtained for this study? Yes • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jun 28, 2024 • Manual Googling: Oct 29, 2024 • iThenticate Software: Nov 04, 2024 (9%) ETYMOLOGY: Author Origin EMENDATIONS: 8 |
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