Original article / research
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Year :2021
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Month :
July
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Volume :
10
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Issue :
3
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Page :
RO21 - RO24
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Diffusion Weighted Imaging on a 3 Tesla Magnetic Resonance Scanner as a Diagnostic Tool in Early Detection of Prostate Cancer
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Ruchira Das, Archana Singh, Sudipta Saha, Shubham Saha, Dilip Kumar Pal, Utpalendu Das, Madan Karmakar
1. Consultant Radiologist, Department of Radiodiagnosis, Warrington and Halton Teaching Hospitals, NHS Foundation Trust, Warrington, United Kingdom.
2. Associate Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.
3. Assistant Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.
4. Junior Resident, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.
5. Professor, Department of Urology, IPGME&R, Kolkata, West Bengal, India.
6. Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.
7. Professor, Department of Radiodiagnosis, IPGME&R, Kolkata, West Bengal, India.
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Correspondence Address :
Ruchira Das, Archana Singh, Sudipta Saha, Shubham Saha, Dilip Kumar Pal, Utpalendu Das, Madan Karmakar,
Archana Singh,
Department of Radiodiagnosis IPGMER & SSKM Hospital 244 AJC Bose Road,
Kolkata, West Bengal, India.
E-mail: asinghrd@gmail.com
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| | | ABSTRACT |  |
: Introduction: Multiparametric Magnetic Resonance Imaging (MRI) of prostate including Diffusion Weighted Imaging (DWI) is greatly evolving as a diagnostic tool in prostate cancer. Incidence of prostate cancer in India is on rise with most of the cases been diagnosed in late stages. In this scenario, DWI imaging can pick up the cases at an earlier stage causing a significant impact in the patient management.
Aim: To assess the role of DW-MRI as a non-invasive initial investigation tool in prostate carcinoma prior to biopsy.
Materials and Methods: The study was a prospective observational study conducted during April 2014 to March 2015 in the Department of Radiodiagnosis in collaboration with Department of Urology in a hospital in Kolkata. A total of 34 patients with a clinical suspicion of prostate cancer underwent prostate DW-MRI by a 3T scanner before Transrectal Ultrasound (TRUS)-guided biopsies. IBM Statistical Package for Social sciences (SPSS) version 17.0 was used for statistical analysis and the sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were determined.
Results: All patients (100%) with biopsy proven adenocarcinoma showed diffusion restriction. 95.8% were PI-RADS 5. False positive results were found in two patients. The sensitivity, specificity, PPV and NPV were 100% (95% CI= 85.75% to 100.00%), 80% (95% CI= 44.39% to 97.48%), 92.31% (95% CI= 74.87% to 99.05%) and 100% (95% CI=63.06% to 100.00%)
Conclusion: From the present study, it was noted that sensitivity of DWI is very high (100%). DWI also has a high specificity and positive predictive value. Hence, DWI is one of the most effective adjunct noninvasive tools for initial investigation in prostate carcinoma which improves the diagnostic performance and helps in performing targeted biopsies from the suspicious prostatic lesion.
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Keywords :
Biopsy, Diagnostic imaging, Magnetic resonance imaging, Prostate carcinoma
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DOI and Others :
10.7860/IJARS/2021/48949:2668
Date of Submission: Feb 10, 2021
Date of Peer Review: Feb 19, 2021
Date of Acceptance: Feb 24, 2021
Date of Publishing: Jul 01, 2021
AUTHOR DECLARATION:
• Financial or Other Competing Interests: None
• Was Ethics Committee Approval obtained for this study? Yes
• Was informed consent obtained from the subjects involved in the study? Yes
• For any images presented appropriate consent has been obtained from the subjects. Yes
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