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Pituitary Stalk Interruption Syndrome: A Case Series Highlighting the Diagnostic Utility of MRI |
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Jyoti Choudhary, Deepshikha Arora, Avinash Dhok, Chetana Ratnaparkhi, Ashwini Umredkar 1. Assistant Professor, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. 2. Junior Resident, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. 3. Professor and Head, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. 4. Additional Professor, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. 5. Associate Professor, Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences (AIIMS), Nagpur, Maharashtra, India. |
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Correspondence Address : Dr. Chetana Ratnaparkhi, Additional Professor, Department of Radiodiagnosis, AIIMS Nagpur, Mihan- 441108, Nagpur, Maharashtra, India. E-mail: chetanaratnaparkhi@aiimsnagpur.edu.in |
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| ABSTRACT |  | ||||||
: Pituitary Stalk Interruption Syndrome (PSIS) is a rare congenital anomaly characterised by an interrupted or thin pituitary stalk, hypoplasia of the anterior pituitary and an absent or Ectopic Posterior Pituitary (EPP). Clinically, this condition manifests as pituitary gland dysfunction, which may include Growth Hormone Deficiency (GHD), global pituitary insufficiency and developmental delay. Early diagnosis is crucial, as delayed recognition can result in suboptimal growth outcomes. Magnetic Resonance Imaging (MRI) of the brain plays a pivotal role in identifying pituitary gland abnormalities associated with PSIS. The present case series describes five patients (3 males, 2 females) and highlights the importance of brain MRI in diagnosing PSIS, emphasising the significance of early intervention to optimise patient outcomes. Early diagnosis and initiation of hormone replacement therapy are essential in improving clinical outcomes. | |||||||
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| Keywords : Anterior pituitary, Developmental delay, Growth hormone, Hypoplasia, Magnetic resonance imaging, Pituitary gland dysfunction | |||||||
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DOI and Others :
DOI: 10.7860/IJARS/2026/80761.3084
Date of Submission: May 23,2025 Date of Peer Review: Aug 18, 2025 Date of Acceptance: Oct 10, 2025 Date of Publishing: Mar 01, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Jun 03, 2025 • Manual Googling: Oct 03, 2025 • iThenticate Software: Oct 09, 2025 (5%) ETYMOLOGY: Author Origin EMENDATIONS: 6 |
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