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Acute Necrotising Encephalopathy of Childhood: A Case Series with Emphasis on Radiological Features |
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Vasudha Battula, Vaishnavi Pantham, Chandrasekhar Patil, Venkata Ramya Ananthu, Hyndavi Padmini Kalluri 1. Assistant Professor, Department of Paediatrics, Mallareddy Medical College for Women, Hyderabad, Telangana, India. 2. Resident, Department of Radiology, Mallareddy Medical College for Women, Hyderabad, Telangana, India. 3. Assosiate Professor, Department of Radiology, Mallareddy Medical College for Women, Hyderabad, Telangana, India. 4. Resident, Department of Radiology, Mallareddy Medical College for Women, Hyderabad, Telangana, India. 5. Fellow in Pediatric Critical Care, Ankura Hospital for Women and Children, Hyderabad, Telangana, India. |
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Correspondence Address : Vasudha Battula, Mallareddy Medical College for Women, Hyderabad, Telangana, India. E-mail: vasu.winny@gmail.com |
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| ABSTRACT |  | ||||||
: Acute Necrotising Encephalopathy (ANE), also known as Acute Necrotising Encephalopathy of Childhood (ANEC), is a rare and fulminant encephalopathy, usually triggered by viral infections, characterised by rapid neurological decline and distinctive neuroimaging features, particularly bilateral thalamic involvement. The authors, here present three cases of ANE, one with a rapid catastrophic presentation with shock, seizures and encephalopathy, where the 10-month-old male child had uncal herniation within four hours of admission, the second one involved eight-year-old boy who had acute encephalopathy and seizures, and the third one who was an adolescent female aged 17 years, had a less severe presentation of mild irritability and aphasia. The present case series underscores the pivotal role of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) in early diagnosis of ANE. The case series also highlights the importance of early, aggressive immunomodulation to achieve favourable outcomes in ANEC. | |||||||
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| Keywords : Magnetic resonance imaging, Paediatric neurology, Symmetrical lesions, Thalamic involvement | |||||||
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DOI and Others :
DOI: 10.7860/IJARS/2026/88028.3105
Date of Submission: Feb 05, 2026 Date of Peer Review: Mar 06, 2026 Date of Acceptance: May 07, 2026 Date of Publishing: Jul 01, 2026 AUTHOR DECLARATION: • Financial or Other Competing Interests: None • Was informed consent obtained from the subjects involved in the study? Yes • For any images presented appropriate consent has been obtained from the subjects. Yes PLAGIARISM CHECKING METHODS: • Plagiarism X-checker: Mar 06, 2026 • Manual Googling: Apr 29, 2026 • iThenticate Software: May 06, 2026 (1%) ETYMOLOGY: Author Origin EMENDATIONS: 8 |
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