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Year :2026
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Month :
March-April
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Volume :
15
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Issue :
2
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Page :
RS01 - RS04
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Pituitary Stalk Interruption Syndrome: A Case Series Highlighting the Diagnostic Utility of MRI
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Correspondence Address :
Jyoti Choudhary, Deepshikha Arora, Avinash Dhok, Chetana Ratnaparkhi, Ashwini Umredkar,
Dr. Chetana Ratnaparkhi,
Additional Professor, Department of Radiodiagnosis, AIIMS Nagpur, Mihan-
441108, Nagpur, Maharashtra, India.
E-mail: chetanaratnaparkhi@aiimsnagpur.edu.in
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Introduction: Pituitary Stalk Interruption Syndrome (PSIS) is a rare congenital anomaly characterised by an interrupted or thin pituitary stalk, hypoplasia of the anterior pituitary and an absent or Ectopic Posterior Pituitary (EPP). Clinically, this condition manifests as pituitary gland dysfunction, which may include Growth Hormone Deficiency (GHD), global pituitary insufficiency and developmental delay. Early diagnosis is crucial, as delayed recognition can result in suboptimal growth outcomes. Magnetic Resonance Imaging (MRI) of the brain plays a pivotal role in identifying pituitary gland abnormalities associated with PSIS. The present case series describes five patients (3 males, 2 females) and highlights the importance of brain MRI in diagnosing PSIS, emphasising the significance of early intervention to optimise patient outcomes. Early diagnosis and initiation of hormone replacement therapy are essential in improving clinical outcomes.
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